Description

A postdoctoral position is available at the Center for Stem Cell & Organoid Medicine (CuSTOM) at Cincinnati Children's Hospital.The Helmrath lab seeks a motivated collaborative postdoctoral fellow to investigate single cell genomics of human GI organoids in regenerative medicine. Studies will focus on bioengineering nextgen multilineage organoids and defining the genetic/epigenetic regulation of the mesenchymal niche that supports engraftment during transplantation.

CuSTOM is a multi-disciplinary center of excellence integrating developmental and stem cell biologists, clinicians, bioengineers and entrepreneurs with the common goal of accelerating discovery and facilitating bench-to-bedside translation of organoid technology. Cincinnati Children's Research Foundation is the largest pediatric research institute in the world, with a multibillion-dollar endowment and state-of-the-art facilities including a human pluripotent stem cell facility, CRISPR genome editing, single cell genomics, biomedical informatics, a Nikon Center of Excellence and much more.

MAJOR DUTIES AND RESPONSIBILITIES:
1. Design, execute, and record laboratory experiments; apply standard scientific protocols to experiments, research, and improve current methods and evaluate innovative techniques.
2. Draft, write, and edit scientific reports, papers, journal articles, and abstracts.
3. Design and perform experiments and record data according to research protocol. Independently reproduce, evaluate, research, and improve techniques currently used. Adapt new methods to existing procedures and modify current experiments through scientific knowledge and intuition. Maintain accurate and detailed records of all laboratory work and experiments.
4. Develop, set-up, and verify new procedures in the laboratory. Standardize and establish new published procedures; evaluate innovative techniques. Develop new assays and new protocols; design formats.
5. Discuss relevant insights about experimental results with Faculty and provide useful recommendations and analysis.
6. Maintain an integral role in the laboratory's meetings, presentations, and publications. Present information on research and laboratory work to others at laboratory meetings, journal clubs, and seminars.
7. Troubleshoot and correct erroneous results or problems with laboratory equipment. Maintain and repair equipment; monitor proper use by personnel.
8. Maintain optimal protocol and assay accuracy by conducting regular quality and reproducibility checks.
9. Assist in preparing, writing, and maintaining fiscal budget. Monitor expenditures and prepare capital expenditure requests; track funding, maintain accurate balance, and resolve any discrepancies.
10. Follow policies and procedures governing the handling of confidential information as defined by Cincinnati Children's mission and applicable laws and regulations. Ensure timeliness, accuracy, availability, and security of information.
11. Perform routine procedures, including the collection and analysis of research data, which may affect decisions regarding future patient care.
12. Provide services in a manner to be regularly and conveniently available to meet the needs of Cincinnati Children's research initiatives as determined by department management and Cincinnati Children's governing body.
13. Maintain currency in field through continuing education, literature and seminars. Implement this knowledge into the Department.
14. Recommend approaches for improvement activities, recommend and perform new processes, collect and measure data, develop processes based on performance, and communicate results.
15. Ensure that work areas are organized and present a safe, accessible, effective and efficient environment. Manage attendance at required Cincinnati Children's training sessions, including radiation safety, laboratory safety, bloodborne pathogens, and OSHA. Comply with Infection Control policies and procedures.
16. Participate in establishing job requirements and goals; perform duties at the desired level of competency.
17. Understand, adhere to, and model Core Standards as defined organizationally and specifically within the department/unit.
18. Perform other duties as assigned.

Qualifications

EDUCATION/EXPERIENCE

Required: PhD, MD or equivalent doctoral degree.

Preferred: Successful candidates must hold the PhD, MD, or MD/PhD degrees be highly motivated and have passion for collaborative research. Experience with computational biology and/or human pluripotent stem cells is an advantage.